Exploration of a new drug that targets YAP

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JB Commentary Exploration of a new drug

Yes-associated protein (YAP) has been shown to play a critical role in the growth of various tumours. Phosphorylation of Ser127 of YAP leads to the inhibition of YAP translocation into nucleus and subsequent failure to regulate the expression of target genes that induce cell proliferation. Chemical manipulation of YAP localization or expression may provide an efficient method for cancer treatme...

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ژورنال

عنوان ژورنال: Journal of Biochemistry

سال: 2012

ISSN: 0021-924X

DOI: 10.1093/jb/mvs072